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The mechanism of toxic action BZ

The pharmacological properties substance BZ, as atropine attributed to the anticholinergic action, mainly with M-holinoreaguykh structures. Anticholinergics have a structural similarity with acetylcholine, but unlike him is very slowly hydrolyzed. Once in cholinergic ical synapse, the substance is fixed at BZ receptors, not putting them under significant influence and without action potential. Because cholinergic receptors are occupied by the substance BZ, the acetylcholine does not excite cholinoreceptor ry. Is disturbed significant alone interaction holinoreaktivnye and adrenergic systems with a strong predominance of the last.

When anticholinergics poisoning there was observed the inhibition of activity cholinacetilasa, monoamine oxidase and increasing content in the blood and tissues of epinephrine and norepinephrine.

So, when anticholinergics poisoning observed: on one side is a rough breakdown of the acetylcholine metabolism, associated with inhibition of synthesis of acetylcholine and blockade of cholinergic receptors, and with another — a violation of the metabolism of catecholamines due to inhibition of monoamine oxidase. A long lasting predominance of adrenergic systems. It explains somatic and vegetative disorders, available in the defeat of substance BZ. I guess, in the background, associated with the memory, the importance belongs to the mediator of nerve stimulation acetylcholine.

The high content catecholamines in the blood affects the blood system, responsible for protecting the body if the damage /coagulation, anticoagulation and kinin/, leading to the development giperkaliemical effect. Hypercatecholaminemia also has a pronounced effect on energy and plastic exchanges.

Hypercalcaemia enhances the absorption of oxygen, has a marked glycolytic action, mobilizes fatty acids from adipose tissue, determines contractile activity and metabolism muscle formations. The increased redox processes in the body are affected by substance BZ, the collapse of makroergov, because of psychomotor agitation, leading to the rapid release of energy and hyperthermia, off as one of the leading mechanisms of thermoregulation — fotospuredee.

Activation of bioenergetics and catabolic processes contribute to the development of respiratory and metabolic acidosis.

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